Surrounded by mountains and the sea, tasked with looking over the outstanding natural environments, stands the famed Fuuka Private Academy. In this enormous academy which encompass junior, high and college education in one, flows rumours about the frequent appearances of monsters called "Orphans".

The board chairman of the Academy, Kazahana Mashiro decided that the only way to deal with the Orphans is to gather together a group of girls with special abilities called HiME, to the Academy.

The protaganist, Tokiha Mai knows nothing about this. With her school fees waived as the inducing condition, she has transfered to the Fuuka Private Academy. With the start of the incidents, the latent power in this girl awakens. Even though she fights against her fate, before long she throws herself into the battles to protect those valuable to her. [Anime-Source (dot) com]